Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2

Abstract Plant genomes encode hundreds of receptor kinases and peptides, but the number known plant receptor-ligand pairs is limited. We report that Arabidopsis leucine-rich repeat kinase LRR-RK MALE DISCOVERER 1-INTERACTING RECEPTOR LIKE KINASE 2 (MIK2) for SERINE RICH ENDOGENOUS PEPTIDE (SCOOP) phytocytokines. MIK2 necessary sufficient immune responses triggered by multiple SCOOP suggesting this divergent family peptides. Accordingly, SCOOP12 peptide directly binds triggers complex formation between BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED 1 (BAK1) co-receptor. required resistance to important root pathogen Fusarium oxysporum . Notably, we reveal proteomes SCOOP-like sequences, corresponding synthetic peptides induce MIK2-dependent responses. These results suggest may recognise -derived sequences immunity against The definition SCOOPs as ligands will help unravel roles played during growth, development stress